NCT04365426

Effects of Oral Contraceptives on DNIC in Non-painful Healthy Women

Effects of Oral Contraceptives on Diffuse Noxious Inhibitory Stimulus (DNIC) in Non-painful Healthy Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Universidad Vina del Mar · Academic / Other
• Sex: Female
• Age: 15 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is tu assess the influence of oral contraceptives (OC) on diffuse noxious inhibitory control (DNIC) in healthy women, tested during high, low endogenous estrogens sessions and ovulatory period.

Detailed description

After being informed about the study and it protocol, all patients giving written informed consent, will undergo to a cephalic (masseter) and extracephalic (finger) mechanical stimulus to evaluate the threshold of mechanical pain, and physiological records of systolic/diastolic pressure and heart rates. After, we will evaluate the threshold response and physiological rates to the same mechanical stimulus under a thermal (cold) conditional pain (TCP) at 3 different moments of menstrual period in No contraceptive group (No OC) versus Contraceptive group (CO). Finally, we will compare the mechanical threshold response, physiological rates and pain perception between both groups.

Conditions

• Contraceptive Usage
• Diffuse Noxious Inhibitory Control

Interventions

Type	Name	Description
DEVICE	Mechanical stimulus	Electrical dynamometer to measure mechanical pressure
PROCEDURE	Thermal (cold) stimulus	Water cold bath
OTHER	Oral contraceptive (OC)	Oral contraceptive (OC)
OTHER	No oral contraceptive (No OC)	No oral contraceptive (No OC)

Timeline

• Start date: 2020-04-24
• Primary completion: 2021-01-30
• Completion: 2021-08-30
• First posted: 2020-04-28
• Last updated: 2021-09-28

Locations

1 site across 1 country: Chile