NCT04364854

Speech Entrainment for Aphasia Recovery

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 21 Years – 81 Years
• Healthy volunteers: Not accepted

Summary

After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).

Conditions

• Aphasia
• Aphasia Non Fluent
• Stroke

Interventions

Type	Name	Description
BEHAVIORAL	SET (Speech Entrainment Therapy) 3 weeks	3 weeks of SET which consists of practicing fluent speech in real time with an audio-visual computer program
BEHAVIORAL	SET (Speech Entrainment Therapy) 4.5 weeks	4.5 weeks of SET which consists of practicing fluent speech in real time with an audio-visual computer program
BEHAVIORAL	SET (Speech Entrainment Therapy) 6 weeks	6 weeks of SET which consists of practicing fluent speech in real time with an audio-visual computer program
OTHER	No Therapy 6 Weeks	Participants will not be getting any SET for 6 weeks

Timeline

• Start date: 2020-08-21
• Primary completion: 2024-05-08
• Completion: 2025-08-31
• First posted: 2020-04-28
• Last updated: 2025-11-14
• Results posted: 2025-04-01

Locations

3 sites across 1 country: United States