Trials / Completed
CompletedNCT04360629
Efficacy and Safety of Tranexamic Acid in Cytoreductive Surgery for Ovarian Cancer
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 151 (actual)
- Sponsor
- Jun Zhang · Academic / Other
- Sex
- Female
- Age
- 20 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
Tranexamic acid has been used in surgery for more than 30 years. It's effect on reducing bleeding and blood transfusing has been demonstrated. In our hospital, the amount of cytorsductive surgery for ovarian cancer is big. During the perioperation , bleeding probability is high, and the supply of blood products is limited. In order to reduce bleeding, we're planning to use tranexamic acid in the operations. In this experiment, we will observe the efficacy of tranexamic acid in cytoreductive surgery for ovarian cancer, find the best dosage which can reach the desired effect, and the possible side-effect.
Detailed description
We performed a single blind, prospective, randomised control trial (RCT) . The patients randomised assigned to three groups. Low dose TXA, high dose TXA or a placebo of IV saline which will be infused prior to skin incision in patients undergoing elective cytorsductive surgery for ovarian cancer . Intraoperative blood loss will be estimated by the volume in the suction drains and by weighing the swabs. Postoperative blood loss will be estimated by the volume in the drains. The other secondary outcomes will be inclued perioperation transfusion volume, thromboembolic complications, ICU length of stay (LOS), hospital LOS, adverse thrombogenic events within 30 days, 30-day all-cause readmission and so on.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tranexamic Acid | Tranexamic Acid will be given through central vein |
| DRUG | normal saline | normal saline will be given through central vein |
Timeline
- Start date
- 2020-06-03
- Primary completion
- 2021-12-30
- Completion
- 2021-12-30
- First posted
- 2020-04-24
- Last updated
- 2022-06-01
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04360629. Inclusion in this directory is not an endorsement.