NCT04359394

International Rare And Severe Psoriasis Expert Network

International Rare And Severe Psoriasis Expert Network (IRASPEN) - A Prospective Registry With Genotype-Phenotype Correlation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 6 Months
• Healthy volunteers: Not accepted

Summary

This registry is a prospective observational study in order to describe primarily the natural course of PP subtypes and to gain detailed information about their phenotype.

Detailed description

This project is to describe the natural course of disease in different subtypes of PP. The network builds on a static registry that was based on a one-time clinical characterization of PP patients in Europe (ERASPEN). The International Rare and Severe Psoriasis Expert Network (IRASPEN) already has multiple clinicians involved who have successfully characterized and included their patients in ERASPEN. IRASPEN addresses the question of temporal evolution of clinical features and is actually a non-interventional prospective registry that aims to describe the clinical course and responses to already established treatments of a large number of PP patients over a period of 5 years. The data collection with this registry will give insight on the natural course of PP disease revealing the burden of disease including frequency and severity of flares and the role of therapeutic interventions.

Conditions

• Pustular Psoriasis (PP)

Interventions

Type	Name	Description
OTHER	biological sampling	In order to investigate the level of molecular pathophysiology, blood and punch biopsies will be collected of each patient. In up to two relatives per patient, 30mL blood will be collected only once.
OTHER	Phenotypic description	Phenotypic characterization of the patient's clinical features
OTHER	Photography	All affected areas will be photographed at each visit with 2-dimensional standardized photography

Timeline

• Start date: 2021-09-22
• Primary completion: 2030-12-01
• Completion: 2030-12-01
• First posted: 2020-04-24
• Last updated: 2024-05-09

Locations

8 sites across 6 countries: Germany, Italy, Portugal, Singapore, Switzerland, Turkey (Türkiye)