NCT04358965

Tranexamic Acid Versus Vaginal Misoprostol in Abdominal Myomectomy

Evaluating Safety and Efficacy of Tranexamic Acid Versus Vaginal Misoprostol in Reducing Intraoperative Blood Loss During Abdominal Myomectomy

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 162 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

the aim of the present study is to evaluate safety and efficacy of tranexamic acid versus vaginal misoprostol in reducing intraoperative blood loss during abdominal myomectomy

Conditions

• Myomectomy

Interventions

Type	Name	Description
DRUG	intravenous tranexamic acid	patients will be given a single bolus IV injection of 15 mg/kg of tranexamic acid (TXA) 20 minutes before surgical incision plus one vaginal placebo tablet 60 minutes before skin incision.
DRUG	vaginal misoprostol	patients will be given one vaginal misoprostol tablet (200 mcg) 60 minutes before skin incision and a normal saline IV bolus 20 minutes before surgical incision
DRUG	placebo	patients will be given one vaginal placebo tablet 60 minutes before skin incision and a normal saline IV bolus 20 minutes before surgical incision

Timeline

• Start date: 2020-05-10
• Primary completion: 2020-10-10
• Completion: 2020-10-30
• First posted: 2020-04-24
• Last updated: 2020-04-24