NCT04358718

Influence of Opioids on Circulating Tumor Cells in Radical Cystectomy

Influence of Peri-operative Opioids on Circulating Tumor Cells in Patients Undergoing Robot-Assisted Laparoscopic Radical Cystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Multiple lines of evidence have shown that perioperative opioids requirement was associated with poor outcomes in cancer patients, including increased cancer progression and metastases and reduced survival in patients with lung, breast, prostate, and bladder cancer. Circulating tumor cells (CTCs) have been validated as prognostic biomarkers of a number of cancers. The aim of this study is to investigate the effects of perioperative opioids on the number of CTCs in patients receiving robot-assisted laparoscopic radical cystectomy. The difference of the amounts of perioperative opioids is achieved by using general anesthesia combined with intravenous opioid-based analgesia intra- and post-operatively in one group and general analgesia combined with epidural ropivacaine-based analgesia in the other group.

Conditions

• Bladder Cancer

Interventions

Type	Name	Description
PROCEDURE	general anesthesia	Patients will receive intraoperative and postoperative intravenous opioid-based analgesia for robot-assisted laparoscopic radical cystectomy.
PROCEDURE	general anesthesia combined with epidural analgesia	Patients will receive epidural ropivacaine-based analgesia for robot-assisted laparoscopic radical cystectomy.

Timeline

• Start date: 2020-06-02
• Primary completion: 2020-12-21
• Completion: 2021-01-21
• First posted: 2020-04-24
• Last updated: 2021-08-09

Locations

1 site across 1 country: China