NCT04358692

Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis

Epicardial Measurement of Myocardial Stiffness on Beating Heart and Non-beating Heart During a Programmed Surgical Aortic Valve Replacement for Aortic Stenosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 98 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Elastography is a new non-invasive medical technique for measuring the stiffness at a distance from a tissue. Recent advances in the development of elastography sequences for cardiac exploration suggest a more clinical approach to cardiac elastography. This study propose to compare myocardial stiffness of a group of coronary bypass patients without hypertrophic left ventricular remodeling or sequelae of myocardial infarction versus a group of patients who should benefit from a surgical aortic valve replacement for aortic stenosis. The hypothesis is that the physiological adaptation to pressure overload constituted by aortic stenosis is responsible for a significant increase in myocardial stiffness compared to a reference group.

Conditions

• Aortic Valve Stenosis

Interventions

Type	Name	Description
DEVICE	Aixplorer Mach30	To measure myocardial stiffness by ShearWave elastography on not beating heart

Timeline

• Start date: 2020-06-30
• Primary completion: 2024-06-14
• Completion: 2024-06-14
• First posted: 2020-04-24
• Last updated: 2025-09-10

Locations

2 sites across 1 country: France