NCT04357002

Intravenous Tranexamic Acid Versus Vaginal Dinoprostone in Abdominal Myomectomy

Evaluating Safety and Efficacy of Intravenous Tranexamic Acid Versus Vaginal Dinoprostone in Reducing Intraoperative Blood Loss During Abdominal Myomectomy: a Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

the aim of the present study is to evaluate safety and efficacy of intravenous tranexamic acid versus vaginal dinoprostone in reducing intraoperative blood loss during abdominal myomectomy

Conditions

• Myomectomy

Interventions

Type	Name	Description
DRUG	intravenous tranexamic acid	patients will be given a single bolus IV injection of 15 mg/kg of tranexamic acid (TXA) 20 minutes before surgical incision plus one vaginal placebo tablet 60 minutes before skin incision.
DRUG	vaginal dinoprostone	patients will be given one vaginal dinoprostone tablet (3mg) 60 minutes before skin incision and a normal saline IV bolus 20 minutes before surgical incision
DRUG	vaginal placebo	patients will be given one vaginal placebo tablet 60 minutes before skin incision and a normal saline IV bolus 20 minutes before surgical incision

Timeline

• Start date: 2020-04-30
• Primary completion: 2020-10-01
• Completion: 2020-10-15
• First posted: 2020-04-22
• Last updated: 2020-04-22