NCT04355663

Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity

Neuroproprioceptive Facilitation and Inhibition Physical Therapy Activates Adaptive and Plastic Changes in the Central Nervous System

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (actual)
• Sponsor: Charles University, Czech Republic · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study investigates whether neuroproprioceptive "facilitation, inhibition" physical therapy induces plastic and adaptive processes of the CNS (white matter integrity changes), if they relate to clinical improvement, and whether therapeutic effect differs between different kinds of therapies.

Detailed description

In the Multi-Arm Parallel-Group Exploratory Trial, patients with multiple sclerosis were divided into three groups by an independent study coordinator, and underwent three kinds of neuroproprioceptive "facilitation, inhibition" physical therapy. At baseline and after the end of the two months' therapeutic program, a blinded assessor evaluated clinical outcomes and data from DTI .

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
BEHAVIORAL	Motor program activating therapy	Pacients underwent two months' therapy consisted of 16 face-to-face sessions (1 hour, twice a week for two months).
BEHAVIORAL	Vojta's reflex locomotion	Pacients underwent two months' therapy consisted of 16 face-to-face sessions (1 hour, twice a week for two months).
BEHAVIORAL	Functional electric stimulation	Pacients uderwent two months' therapy. They used the whole time Functional electric stimulation during activities of daily living and underwent 2 individual sessions of Motor program activating therapy.

Timeline

• Start date: 2015-05-20
• Primary completion: 2017-05-20
• Completion: 2019-08-01
• First posted: 2020-04-21
• Last updated: 2020-07-17
• Results posted: 2020-07-17