NCT04353362

Alternative Antibiotic Regimen in Periodontitis Treatment

Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Istanbul Medipol University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Context and Aims: Several studies have demonstrated an association between obesity, periodontitis, and exercise. This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. Settings and Design: A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). Methods and Material: The study sample comprised fifteen patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Statistical analysis used: MedCalc was used for statistical analysis.

Conditions

• Amoxicillin
• Metronidazole
• Ofloxacin
• Periodontitis
• Root Planing

Interventions

Type	Name	Description
DRUG	Ofloxacin	400 mg, 1 time per day for 5 days
DRUG	Amoxicillin	500 mg, 3 times per day for 7 days
DRUG	Metronidazole	500 mg, 3 times per day, for 7 days

Timeline

• Start date: 2017-04-01
• Primary completion: 2020-01-02
• Completion: 2020-03-10
• First posted: 2020-04-20
• Last updated: 2020-04-20

Locations

1 site across 1 country: Turkey (Türkiye)