NCT04352322

Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis

Effectiveness of Oral Hyaluronic Acid (A+ HA(tm), TOP Pharm.) in Knee Osteoarthritis: Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

This study was a randomized, double-blind, placebo-controlled study evaluating the efficacy of an oral liquid HA supplement (A+HA) in symptoms relief and improvement of quality of life in knee osteoarthritis patients with mild knee pain.

Detailed description

Subjects were initially screened at the Randomization/Baseline Visit (Week 0). Eligible subjects were randomized at the same visit into the treatment period and received the assigned treatment in a double-blind fashion for 8 weeks. During the 8 weeks treatment period, there were three follow-up visits requested (Week 2, Week 4 and Week 8). Efficacy was measured by using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Short Form-36 (SF-36).

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	A+HA(tm)	oral solution of hyaluronic acid mixture in combination with glucosamine and chondroitin
DIETARY_SUPPLEMENT	Placebo	oral solution with no active ingredients

Timeline

• Start date: 2012-01-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2020-04-20
• Last updated: 2020-04-20

Locations

1 site across 1 country: Taiwan