NCT04350489

IL-32 Isoforms Levels in GCF and Plasma of the Patients With Periodontitis

Increased Levels of Interleukin-32 Isoforms Alpha, Beta, Gamma, and Delta in the Gingival Crevicular Fluid and Plasma of the Patients With Periodontitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Bulent Ecevit University · Academic / Other
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (GCF) and plasma before and after nonsurgical periodontal treatment in patients with periodontitis (P).Twenty-seven P and 27 periodontally healthy controls (C) were recruited in this study. Periodontitis patients were performed nonsurgical periodontal treatment. GCF and plasma sampling and clinical periodontal parameters were evaluated before and 1 month after treatment. Enzyme-linked immunosorbent assay was used to analyze the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in GCF and plasma samples.

Conditions

• Periodontitis

Interventions

Type	Name	Description
OTHER	Non-surgical periodontal treatment	Conventional non-surgical periodontal treatment were performed

Timeline

• Start date: 2017-10-01
• Primary completion: 2019-05-01
• Completion: 2019-05-01
• First posted: 2020-04-17
• Last updated: 2020-04-20

Locations

1 site across 1 country: Turkey (Türkiye)