Trials / Completed
CompletedNCT04346719
Percutaneous High Frequency Alternating Current Stimulation in Healthy Volunteers
Percutaneous High Frequency Alternating Current Stimulation: Effects on Somatosensory and Motor Threshold in Healthy Volunteers
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- University of Castilla-La Mancha · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
High-frequency alternating currents of greater than 1 kHz applied on peripheral nerves has been used in animal studies to produce a motor nerve block. It has been evidenced that frequencies higher than 5 kHz are necessary to produce a complete peripheral nerve block in primates, whose nerve thickness is more similar to humans.
Detailed description
Our previous studies with transcutaneous HFAC, suggest high-frequency stimulation (10 and 20 kHz) have an inhibitory effect over muscle strength and somatosensory threshold. However, in these studies the intensity needed to reach block threshold is very high. The purpose of the present work is to reduce the amount of current intensity needed using a percutaneous approach by apply two acupuncture needles near the nerve as electrodes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | 10 kHz stimulation (Myomed 932, Enraf-Nonius) | A charge-balanced, symmetric, biphasic sinusoidal current without modulation will be delivered at a frequency of 10 kHz. The stimulation intensity will be defined as that sufficient to produce a "strong but comfortable" sensation, just below motor threshold, over the median nerve through the electrotherapy device Myomed 932. (Enraf-Nonius, Delft,Netherlands) |
| DEVICE | 20 kHz stimulation (Myomed 932, Enraf-Nonius) | A charge-balanced, symmetric, biphasic sinusoidal current without modulation will be delivered at a frequency of 20 kHz. The stimulation intensity will be defined as that sufficient to produce a "strong but comfortable" sensation, just below motor threshold, over the median nerve through the electrotherapy device Myomed 932. (Enraf-Nonius, Delft,Netherlands) |
| DEVICE | Sham stimulation (Myomed 932, Enraf-Nonius) | Sham stimulation will be delivered at a frequency of 10 kHz only during the first 30 seconds. |
Timeline
- Start date
- 2020-06-01
- Primary completion
- 2020-11-17
- Completion
- 2020-11-17
- First posted
- 2020-04-15
- Last updated
- 2020-11-18
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT04346719. Inclusion in this directory is not an endorsement.