NCT04342065

Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery

Efficacy of Pre-emptive Different Doses of Oral Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Patients Subjected for Elective Lumbar Spine Fixation Surgery: a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: South Egypt Cancer Institute · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory drugs (NSAID) such as celecoxib were used as a part of multimodal analgesia to control such pain. Gabapentin is an anticonvulsant drug that has analgesic effect in post-herpetic neuralgia, diabetic neuropathy, and neuropathic pain. Celecoxib is one of the NSAIDs, that its analgesic effect is reported in various studies by cyclooxygenase-2 (COX-2) inhibitor. The aim of this randomized double-blinded study was to asses and compare the efficacy of using gabapentin versus celecoxib as a part of multimodal analgesia in perioperative hemodynamic control and pain relief in patients underwent posterior approach lumbar spine disc fixation surgery.

Conditions

• Post-Operative Pain

Interventions

Type	Name	Description
DRUG	Celecoxib capsules	received celecoxib 200 mg 2 hours preoperative and the same dose 6 hours postoperative.
DRUG	Pregabalin 150mg	received Pregabalin 150mg 2 hours preoperative and the same dose 6 hours postoperative.

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-01-30
• Completion: 2020-02-01
• First posted: 2020-04-10
• Last updated: 2020-04-14

Locations

1 site across 1 country: Egypt