NCT04340128

Efficacy of Intra-lesional Injections of Glucantime Once a Week or Twice a Week in the Treatment of Anthroponotic Cutaneous Leishmaniasis (ACL)

Evaluation of Efficacy of Intra-lesional Injections of Glucantime Once Weekly in Comparison With Twice Weekly in the Treatment of Acute Anthroponotic Cutaneous Leishmaniasis (ACL)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: —
• Sponsor: Tehran University of Medical Sciences · Academic / Other
• Sex: All
• Age: 9 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Anthroponotic Cutaneous Leishmaniasis (ACL) is a parasitic disease caused by Leishmania tropica, pentavalent antimonials (sodium stibogluconate and meglumine antimoniate) have been used as a standard treatment for leishmaniasis for last 80 years. Systemic antimonial injection is painful, toxic, not affordable and moreover is not always effective. Many different modalities are used to treat the disease with a limited success. Intra-lesional injections of antimonials are used for the treatment of patients with a few lesions but no data is available on the rate of efficacy. In this study the efficacy of intra-lesional injections of Glucantime weekly is compared with intra-lesional injections of Glucantime twice weekly.

Conditions

• Cutaneous Leishmaniasis

Interventions

Type	Name	Description
DRUG	Meglumine antimoniate	Intra-lesional injection once a week, 0.1/cm2
DRUG	Meglumine antimoniate	Intra-lesional injection twice a week, 0.1/cm2

Timeline

• Start date: 2007-05-01
• Primary completion: 2007-10-01
• Completion: 2007-12-01
• First posted: 2020-04-09
• Last updated: 2020-04-09

Locations

1 site across 1 country: Iran