NCT04336852

Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: University of Illinois at Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to develop a test of cerebral vessel function by inducing a reactive hyperemia that will elicit a rapid and profound increase in cerebral vessel shear stress. The results of this project may lead to development of a test with prognostic/predictive utility for individual risk assessment of a future cerebrovascular event/disease. This information will be of vital importance to the medical community in regards to cerebrovascular health in aging individuals, and testing of interventions and therapies that may ameliorate these effects.

Conditions

• Cerebrovascular Disorders
• Cerebrovascular Disease

Interventions

Type	Name	Description
PROCEDURE	Flow mediated dilation (brachial and femoral arteries)	Assessment of vascular function of the brachial and femoral arteries.
PROCEDURE	Cerebral vascular reactivity to carbon dioxide (CO2)	Cerebral blood flow responses to increasing partial pressure of CO2
PROCEDURE	Cerebral vascular function test	Cerebral blood flow responses to a reactive hyperemia stimulus

Timeline

• Start date: 2018-09-14
• Primary completion: 2023-05-12
• Completion: 2023-05-12
• First posted: 2020-04-07
• Last updated: 2025-05-20

Locations

2 sites across 1 country: United States