NCT04333953

COVID-19 in Patients With HIV

Prospective Observational Study for Patients With HIV and Confirmed SARS-CoV-2

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 412 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV who have not achieved viral suppression through antiretroviral treatment may have a compromised immune system that leaves them vulnerable to infections and disease progression. However, little is known about the presentation and clinical outcomes of patients with HIV and SARS-CoV-2. Our aim is to characterize the clinical presentation and disease course of COVID-19 in patients with HIV.

Detailed description

Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV (PWH)/AIDS, or people with HIV who have not achieved viral suppression through antiretroviral treatment may have at higher risk for SARS-CoV-2 infections and disease progression. At present there is no evidence to suggest that there is an increased risk of infection and increased severity of illness for PWH. We know that during the SARS and MERS outbreaks, there were only few case reports of mild disease among PWH. Current clinical data suggest the main mortality risk factors are linked to older age and other co-morbidities. However, some healthy people have also developed severe disease from the SARS-CoV-2 infection. This is a multi-center prospective observational study. Our aim is to characterize the clinical presentation and clinical course of COVID-19 in patients with HIV. Patients with HIV and confirmed SARS-Cov-2 will be identified during routine clinical care in the inpatient or outpatient setting. Contributors will share de-identified demographic data, health history data, and clinical data pertaining the patient's presentation with COVID-19 and outcomes obtained during routine care for their patients, using the secure online data collection tool REDCap.

Conditions

• HIV/AIDS
• COVID-19
• SARS-CoV-2

Interventions

Type	Name	Description
OTHER	No intervention	No intervention, observational study

Timeline

• Start date: 2020-04-01
• Primary completion: 2020-07-01
• Completion: 2022-03-28
• First posted: 2020-04-03
• Last updated: 2022-05-23

Locations

1 site across 1 country: United States