NCT04332952

Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 21 (actual)
• Sponsor: Miguel Ayala León · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory. The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Conditions

• Glycocalyx
• Cardio-Renal Syndrome

Timeline

• Start date: 2017-08-01
• Primary completion: 2017-10-01
• Completion: 2017-12-31
• First posted: 2020-04-03
• Last updated: 2020-04-09

Locations

1 site across 1 country: Mexico