NCT04332705

Cryptosporidium Infection and Human Colorectal Cancer

Role of the Protozoa Cryptosporidium in the Development of Colorectal Cancer in Humans

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 324 (estimated)
• Sponsor: Lille Catholic University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

It has been reported that Cryptosporidium parvum, a species of a protozoan frequently isolated from humans and animals, is able to induce digestive adenocarcinoma in a rodent model. Consistently, some epidemiological studies have reported an association with cryptosporidiosis in patients with colorectal adenocarcinoma. However, the correlation between cryptosporidiosis and human digestive cancer remains unclear at this time, and it is not known whether this intracellular parasite, considered an opportunistic agent, is able to induce gastrointestinal malignancies in humans. In order to add new arguments for a probable association between cryptosporidiosis and digestive human cancer, the main aim of this study is to determine prevalence and to identify species of Cryptosporidium among a French digestive cancer population.

Conditions

• Colonic Neoplasms
• Cryptosporidiosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Detection of Cryptosporidium infection	A biopsy or a surgical sample will be collected from every participant

Timeline

• Start date: 2020-06-30
• Primary completion: 2024-06-30
• Completion: 2024-12-30
• First posted: 2020-04-03
• Last updated: 2023-11-18

Locations

1 site across 1 country: France