Trials / Unknown
UnknownNCT04330807
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 220 (estimated)
- Sponsor
- Centre Hospitalier le Mans · Academic / Other
- Sex
- All
- Age
- 60 Years
- Healthy volunteers
- Accepted
Summary
Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular filtration rate (GFR). Among them, muscle wasting is common and multifactorial, partially explained by an imbalance between protein catabolism and synthesis. Muscular strength is also affected beyond the reduction of the lean body mass, resulting in profound fatigue. The present study seeks to quantify the prevalence of low muscular strength production (dynapenia) in a cohort of elderly patients with advanced CKD, through a maximal voluntary contraction (MVC) handgrip test compared to control data available in the literature, matched in term of age and sex. It also aims to investigate the link between the reported fatigue (subjective) and the evolution of the MVC, called critical force (fcrit) during a fatiguing task (objective fatigability).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Handgrip fatigability test | Dynamometric and electromyographic assessment: patient is sitting on a chair, back upright, humerus vertically placed and forearm landing parallel to a support. Dominant arm is chosen for test and electrodes placement. The assessment is divided in 4 phases for a total of 30 minutes duration: Warm-up, determination of reference force settings (fast sub-maximal contractions and maximal voluntary contractions), fatigability period and rest. |
| OTHER | Questionnaires | Assessment of subjective fatigue with Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Multidimensional Fatigue Inventory (MFI-20) questionnaires |
Timeline
- Start date
- 2020-06-22
- Primary completion
- 2022-06-01
- Completion
- 2022-06-01
- First posted
- 2020-04-02
- Last updated
- 2022-03-23
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04330807. Inclusion in this directory is not an endorsement.