NCT04328311

The Impact of Watermelon Juice on Blood Pressure

The Impact of Watermelon Juice on Blood Pressure in Young Healthy Adults

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Reading · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

L-citrulline is found naturally in watermelon. Recently interest has increased for this amino acid due to potential health benefits. Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide. The study will be an acute single blind, randomised controlled, crossover intervention study in healthy, young volunteers. Participants receive either the test watermelon drink or control drink (water). Blood samples and vascular measures (by a single-cuff based method) will be measured at baseline. Vascular measures will be repeated at 15-minute intervals between 0-2 hours and a second blood sample will be drawn at 1.5 hours to coincide with the estimated peak plasma L-citrulline. Citrulline, arginine and nitric oxide metabolites will be measured in the blood samples.

Conditions

• Healthy Aging

Interventions

Type	Name	Description
OTHER	Watermelon Juice	500 mL watermelon juice (What a Melon), containing \~1 g of L-citrulline.
OTHER	Water	500 mL low nitrate water

Timeline

• Start date: 2020-01-08
• Primary completion: 2022-12-30
• Completion: 2024-12-30
• First posted: 2020-03-31
• Last updated: 2024-11-22

Locations

1 site across 1 country: United Kingdom