NCT04327999

Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System

Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System of Patients Following Radioiodine Therapy for Thyroid Carcinoma

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to explore whether administration of preservative free artificial tears will decrease the level of detectable radioiodine in the tears and nasolacrimal duct system of patients undergoing radioiodine therapy for thyroid carcinoma and thus decrease the risk of developing radioactive iodine associated nasolacrimal duct obstruction.

Detailed description

Primary Objective: \- To assess whether use of preservative free artificial tears following radioactive iodine administration will lower the level of radioactive iodine in the tears of patients treated with radioactive iodine for thyroid carcinoma. Secondary Objective: \- To evaluate whether artificial tears would be an effective preventative intervention to decrease the risk of developing nasolacrimal duct stenosis, which has been associated with radioactive iodine administration.

Conditions

• Thyroid Carcinoma
• Radioactive Iodine Level

Interventions

Type	Name	Description
DRUG	Artificial Tears	Self-Administered - utilizing eye drop preservative free vials

Timeline

• Start date: 2020-10-05
• Primary completion: 2023-09-25
• Completion: 2023-09-25
• First posted: 2020-03-31
• Last updated: 2024-01-18
• Results posted: 2024-01-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study