NCT04327570

In-depth Immunological Investigation of COVID-19.

In-depth Characterisation of the Dynamic Host Immune Response to Coronavirus SARS-CoV-2

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors resulting in hyper-susceptibility to SARS-CoV-2 infection, which is urgently needed for directed medical interventions.

Detailed description

The overall aim of this prospective study is to provide an in-depth characterization of clinical and immunological features of patients hospitalized in UZ Leuven because of SARS-CoV-2 infection. For this purpose, clinical data and blood, nasopharyngeal/rectal swab, and if safe, bronchoalveolar lavage (BAL) fluid and lung tissue samples will be collected from PCR- or CT-confirmed COVID-19 patients, with varying degrees of disease severity. Assessed characteristics will be compared between severe and non-severe COVID-19 patients, and between COVID-19 positive and negative ('control') patients.

Conditions

• Coronavirus Infections

Interventions

Type	Name	Description
OTHER	Patient sampling	Blood draw, NP/rectal swab, bronchoscopy if clinically indicated, lung tissue if applicable

Timeline

• Start date: 2020-03-27
• Primary completion: 2026-03-30
• Completion: 2026-03-30
• First posted: 2020-03-31
• Last updated: 2025-11-17

Locations

1 site across 1 country: Belgium