NCT04327258

The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 437 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Detailed description

Background Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined. Objective The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort. Methods Cross-sectional association study in a cohort of non-cardiac surgery patients. This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Conditions

• Anesthesia
• Surgical Procedure, Operative

Timeline

• Start date: 2011-01-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2020-03-31
• Last updated: 2020-03-31

Locations

1 site across 1 country: Switzerland