NCT04326673

Salivary Testosterone in Men: Diurnal Variation and Post-Prandial Responses

Salivary Testosterone in Men: Diurnal Variation and Post-prandial Responses

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: The Royal Wolverhampton Hospitals NHS Trust · Other Government
• Sex: Male
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose is to evaluate Sal-T against standard biomarkers of male gonadal status based on serum T, calculated free T and BAT. The optimal salivary sampling in terms of fasting and time of day will also be defined. The ultimate aim is to add Sal-T into the Trust's repertoire of tests in investigating suspected hypogonadism in men.

Detailed description

To investigate whether salivary (free) testosterone is subject to similar prandial variations reported for serum total testosterone. Study 1: Assessment of diurnal variation in salivary testosterone adjusted for prandial state in 20 healthy men. Study 2: Measurement of salivary and serum testosterone and related biomarkers before and after a standard 75g oral glucose load in 40 men.

Conditions

• Hypogonadism, Male

Interventions

Type	Name	Description
OTHER	Testosterone Measurements in healthy volunteers after fasting	salivary testosterone measurements taken in morning and evening and a single blood test for testosterone taken
OTHER	Testosterone Measurements after glucose loading	salivary tstosterone and blood testosterone measurements

Timeline

• Start date: 2020-10-30
• Primary completion: 2023-10-30
• Completion: 2023-10-30
• First posted: 2020-03-30
• Last updated: 2025-01-06

Locations

1 site across 1 country: United Kingdom