NCT04326491

The Utility of Breath Biopsy as a Screening Tool for HCC

The Utility of Breath Biopsy as a Screening Tool for HCC: A Pilot Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: University of Aberdeen · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aim of this pilot study is to examine whether there is a discriminating ability of the breath sample analysis to capture biomarkers specific to the HCC in the breath of affected individuals. If positive, our research could open up a new horizon for cost-effective and feasible screening tools.

Detailed description

20 Participants will be included in the study. Ten Cirrhotic patients with HCC and 10 Cirrhotic patients without HCC. The first group is patients with HCC secondary to cirrhosis. The second group will be patients with cirrhosis who are currently on the standard surveillance program with no HCC. Confirmation of the absence of HCC would have been ensured via a recent advanced imaging modality (dynamic CT scan or MRI) in the ongoing surveillance programme. Participants will breathe into either a mouthpiece or collection tube then Breath samples will be analyzed via an analyzer to detect the volatile organic compounds (VOC) and quantitatively compare them

Conditions

• HCC
• Cirrhosis, Liver

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Breath Biopsy	Analysis of breath samples to identify volatile molecules specific to HCC

Timeline

• Start date: 2021-06-20
• Primary completion: 2022-05-16
• Completion: 2022-05-16
• First posted: 2020-03-30
• Last updated: 2022-05-20

Locations

1 site across 1 country: United Kingdom