Trials / Unknown
UnknownNCT04324255
Von Willebrand Factor and Protein C Ratio in Graft Function After Liver Transplant
Von Willebrand Factor and Protein c Ratio-related Thrombogenicity With Systemic Inflammation is Predictive of Graft Dysfunction After Liver Transplantation: Retrospective Cohort Study
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,199 (estimated)
- Sponsor
- Asan Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In liver cirrhosis (LC),the activity of von Willebrand factor (vWF)-cleaving enzyme ADAMTS13 is reduced in LC patients and consequent progression of liver injury. Remarkably, it has been reported that a severe vWF/ADAMTS13 imbalance develops during liver transplantation (LT) and persists even after LT. Such changes are thought to contribute to postoperative thrombotic complications, which may lead to early adverse events of thrombotic microangiopathy after living-donor LT (LDLT). We investigated whether vWFPCR could predict EAD or graft failure following LT and compared it with FVIIIPCR, procoagulant, such as vWF and FVIII and anticoagulant, such as PC.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | LT | Liver transplantation |
Timeline
- Start date
- 2014-01-01
- Primary completion
- 2016-12-30
- Completion
- 2020-04-30
- First posted
- 2020-03-27
- Last updated
- 2020-03-27
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT04324255. Inclusion in this directory is not an endorsement.