NCT04322500

Probiotics for Chalaziosis Treatment in Children

Intestinal Microbiota: a New Target for Chalaziosis Treatment in Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Molise · Academic / Other
• Sex: All
• Age: 3 Years – 14 Years
• Healthy volunteers: Not accepted

Summary

There is growing evidence encouraging the use of probiotics in many conditions in children. The aim of the investigator's study is to define the possible beneficial impact of probiotics on paediatric patients affected by chalaziosis.

Detailed description

Prospective comparative pilot study on 26 children suffering from chalaziosis. They will be randomly divided in two groups. One group will receive conservative treatment and the other one will receive conservative treatment and a daily supplementation of probiotics. All patients will be evaluated at 2-week intervals for 3 months. If the lesion will not disappear or decrease in size to 1 mm or less in diameter on subsequent visits, the same procedure will be repeated for another 3-months cycle. The follow up periods extend from 3 to 6 months according to the results.

Conditions

• Chalazion

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	probiotics	use specific probiotics in addiction to conservative treatment to modify the intestinal microbiome to ameliorate the clinical course of chalaziosis in children by re-establishing intestinal and immune homeostasis
OTHER	conservative treatment	lid hygiene, warm compression, and dexamethasone/tobramycin ointment for at least 20 days

Timeline

• Start date: 2019-02-01
• Primary completion: 2020-02-29
• Completion: 2020-02-29
• First posted: 2020-03-26
• Last updated: 2020-05-05
• Results posted: 2020-04-24

Locations

1 site across 1 country: Italy