NCT04317196

Association of Copy Number Variations in the SMN Genes With Acute Kidney Injury After Heart Surgery

Molecular Epidemiology Study of the Association of Copy Number Variations in the SMN Genes With Acute Kidney Injury After Heart Surgery

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,206 (estimated)
• Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 1 Month – 80 Years
• Healthy volunteers: Not accepted

Summary

This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

Detailed description

This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. Real-time PCR is used to detect copy number variations in the peripheral blood SMN gene on 1206 patients with heart surgery. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

Conditions

• Acute Kidney Injury

Timeline

• Start date: 2020-04-01
• Primary completion: 2021-12-01
• Completion: 2022-09-01
• First posted: 2020-03-23
• Last updated: 2020-05-12

Locations

1 site across 1 country: China