NCT04316390

Influence of Hesperidin and Vitamin C on Uric Acid Concentration

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Kiel · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.

Detailed description

Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks. The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted. During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed. At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.

Conditions

• Higher Uric Acid Concentrations (>5,5 mg/dl)
• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Control	study drink (two weeks)
DIETARY_SUPPLEMENT	Hesperidin	study drink + Hesperidin 600 mg (two weeks)
DIETARY_SUPPLEMENT	Vitamin C	study drink + Vitamin C 250 mg (two weeks)
DIETARY_SUPPLEMENT	Hesperidin + Vitamin C	study drink + Hesperidin 600 mg + Vitamin C 250 mg (two weeks)

Timeline

• Start date: 2022-07-15
• Primary completion: 2023-03-22
• Completion: 2023-03-30
• First posted: 2020-03-20
• Last updated: 2023-07-03

Locations

1 site across 1 country: Germany