NCT04314726

Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction

Usefulness of Amelogenins in the Treatment of Periodontal Defects on the Distal Surface of the Lower Second Molar After Adjacent Third Molar Extraction: a Pilot Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: All
• Age: 18 Years – 27 Years
• Healthy volunteers: Accepted

Summary

Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evaluated the effectiveness of amelogenins. Methods: A single-blind split-mouth randomized controlled clinical trial (RCT) was performed on 5 patients to verify if amelogenins had some benefits in improving lower second molar periodontal healing after adjacent third molar extraction. A PPD ≥ 8 mm associated with a radiographic bone defect of at least 5 mm were the main inclusion criteria.

Conditions

• Attachment Loss, Periodontal
• Teeth, Impacted

Interventions

Type	Name	Description
DRUG	Amelogenin	amelogenins applied on the distal surface of the lower second molar after adjacent third molar extraction
DRUG	Placebos	placebo applied on the distal surface of the lower second molar after adjacent third molar extraction

Timeline

• Start date: 2016-03-24
• Primary completion: 2018-04-20
• Completion: 2018-04-20
• First posted: 2020-03-19
• Last updated: 2020-03-19