NCT04307667

Microglia Activation in Asthma

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trail is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 6 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test * Undergo breathing tests including two whole lung allergen challenges * Give four blood samples * Complete brain imaging scans

Conditions

• Asthma

Interventions

Type	Name	Description
BIOLOGICAL	Whole lung antigen challenge (WLAC)	Whole lung antigen challenge with cat hair, house dust mite, or short ragweed allergen extracts.
RADIATION	[18F]FEPPA	\[18F\]FEPPA is a radiotracer selective for translocator protein (TSPO) binding, which is elevated in activated microglia.

Timeline

• Start date: 2019-12-17
• Primary completion: 2028-08-01
• Completion: 2028-08-01
• First posted: 2020-03-13
• Last updated: 2025-08-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study