NCT04305366

MicroRNA Markers in Head and Neck Cancers

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 225 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the presence of miRNA markers in saliva, blood, FNA and tissue specimens in patients with and without head and neck cancer and evaluate whether these miRNA markers can provide prognostic or diagnostic clinical significance in the treatment of head and neck cancer patients.

Detailed description

Micro RNA (miRNA) markers were initially discovered in 1993 and recent research has shown that they have great potential for use as both surveillance and prognostic markers in cancer treatment, as well as potential targets for cancer therapy. Recent research has identified several miRNA markers which appear to be potential markers for head and neck squamous cell carcinoma, and these have been tested in both mouse and human banked tumor samples. These investigators hypothesize that these markers may also be present in other tissues, including fine needle aspiration biopsy, blood, and saliva specimens, and will be sensitive and specific to patients with known head and neck cancer.

Conditions

• Squamous Cell Carcinoma of Head and Neck

Interventions

Type	Name	Description
OTHER	Tissue collection	Blood draw, Fine Needle Aspiration, Saliva Swab, Tumor/tissue sample

Timeline

• Start date: 2012-11-16
• Primary completion: 2022-12-20
• Completion: 2027-02-01
• First posted: 2020-03-12
• Last updated: 2026-02-24

Locations

1 site across 1 country: United States