NCT04302987

Vitamin D Intervention in Infants - 6 Years Follow-up (VIDI2)

VITAMIN D INTERVENTION IN INFANTS: Effects of Early Vitamin D Exposure on Childhood Health at 6 Years - a Follow-up Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 415 (actual)
• Sponsor: University of Helsinki · Academic / Other
• Sex: All
• Age: 6 Years – 7 Years
• Healthy volunteers: Accepted

Summary

Exposure to vitamin D intervention in early life may have permanent effects on physiology and metabolism. Bone growth and mineralization, development of immunity, body composition and brain structure and functioning may be affected. The importance of a long-term surveillance includes follow-up of both beneficial but also harmful effects of vitamin D. Vitamin D intervention in infants (VIDI) study was conducted in 2013-2016. VIDI study was a large randomized trial that aimed to evaluate effects of two vitamin D supplemental doses of daily 10 ug and 30 ug from the age 2 weeks until 2 years on bone strength, infections, immunity, allergy, atopy and asthma, neurologic and cognitive development, and genetic regulation of mineral homeostasis. Current study is a 6 Years Follow-up (VIDI2) study of the original VIDI trial. Our focuses of interest in the follow-up are: bone strength, growth pattern, body composition, and morbidity due to infections and allergic diseases, and the development of immunity. Further, in addition to more classical associates of vitamin D, our aim is to continue to follow-up children's neurocognitive development and mental health. We will also focus on the effect of vitamin D supplementation on occurrence of molar-incisor hypomineralization, dental caries, and oral immunity.

Conditions

• Bone Strength
• Growth
• Body Composition
• Infection
• Allergic Diseases
• Dental Health

Timeline

• Start date: 2019-11-01
• Primary completion: 2021-12-15
• Completion: 2022-05-27
• First posted: 2020-03-10
• Last updated: 2022-11-03

Locations

1 site across 1 country: Finland