NCT04298944

Association of Mood With Risk for Atherosclerosis

AuRA Study: Association of Mood With Risk for Atherosclerosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 37 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 22 Years
• Healthy volunteers: —

Summary

The investigators will aim to determine the association of mood disorders (MDO) with preclinical and clinical cardiovascular (CVD) risk factors among children. The investigators will also aim to identify traditional and non traditional predictors of CVD risk among children with MDO.

Detailed description

This research is being done to determine if mood disorders in children have an impact on stiffness of arteries and/or cause the arteries to not work as well and if MDOs impact blood pressure over a 24 hour period of time.The investigators also want to determine if children with mood disorders have any risk factors or blood tests that can predict how stiff arteries are or how well arteries function and if these are associated with cardiovascular disease risk. The investigators also want to determine if children with mood disorders have greater adverse childhood experiences, worse emotional regulation and poorer quality of sleep. The investigators hope that information from this study could help in earlier detection of cardiovascular disease risk in children.

Conditions

• Mood Disorders
• Hypertension
• Overweight and Obesity
• Vascular Stiffness
• Sleep
• Elevated Blood Pressure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiovascular Assessments	Participants will undergo the following cardiovascular assessments: 24-hour blood pressure monitoring, arterial stiffness measurements, endothelial function measurements.
DIAGNOSTIC_TEST	Actigraphy	Participants will wear an actigraph device for 7 days to measure participant's activity and sleep
DIAGNOSTIC_TEST	Laboratory assessments	Participants will provide blood and urine samples for laboratory assessments.
BEHAVIORAL	Emotional/ Behavioural assessments	Emotional /Behavioral well being will be determined by questionnaires: Pediatrics Adverse Childhood Experiences Questionnaire (ACEs Q), Childrens Emotion Management Scale Questionnaire (CEMS) and Behavior Assessment System for Children (BASC)

Timeline

• Start date: 2020-03-11
• Primary completion: 2022-05-31
• Completion: 2022-05-31
• First posted: 2020-03-06
• Last updated: 2022-08-23

Locations

1 site across 1 country: United States