NCT04296487

Introduction of ACI for Cartilage Repair

Introduction of Autologous Chondrocyte Implantation Procedure for the Treatment of Chondral Defect in the Knee

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 218 (estimated)
• Sponsor: Centre Hospitalier Universitaire Vaudois · Academic / Other
• Sex: All
• Age: 15 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.

Detailed description

* Prospective and interventional study * All procedures are carried out after obtaining informed written consent from patients. * Study procedures involve a biopsy, cell production, cell implantation and follow-up including a strict post-surgery rehabilitation protocol (12 month timepoint) * All subjects will be assessed at intervals post-implantation (6 weeks, 3 months, 6 months and 12 months). * Measures to assess effectiveness and safety will be conducted at follow-ups: Magnetic Resonance Imaging (MOCART score), collection of adverse events, orthopaedic scores (KOOS, IKDC, SF12v2)

Conditions

• Articular Cartilage Defect
• Chondral Defect
• Osteochondritis

Interventions

Type	Name	Description
OTHER	autologous chondrocytes	autologous chondrocytes implantation (ACI)

Timeline

• Start date: 2017-09-01
• Primary completion: 2030-09-01
• Completion: 2030-09-01
• First posted: 2020-03-05
• Last updated: 2026-03-11

Locations

1 site across 1 country: Switzerland