NCT04292249

Predictive Value of suPAR and hsCRP on Postoperative Mortality in Cardiac Surgery

Predictive Value of suPAR and hsCRP on Postoperative Mortality in 951 Patients Undergoing Elective On-pump Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 951 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate whether preoperative soluble urokinase plasminogen activating receptor (suPAR) and High-sensitivity C-Reactive Protein (hsCRP) are independent markers of death after cardiac surgery. Further, to assess whether suPAR and hsCRP provides increased predictive accuracy of the clinical risk model EuroSCORE II. The purpose of the study is to gain knowledge on whether these inflammatory biomarkers might be able to reveal a pro-inflammatory disease state that represents a significant risk in patients undergoing cardiovascular surgery. Hence, these biomarkers may assist clinicians in selecting compassionate treatment for high risk patients.

Conditions

• Thoracic Surgery
• Cardiac Surgical Procedures
• Biomarkers

Interventions

Type	Name	Description
OTHER	Blood sampling	Analysis will be performed using commercially available analyses (suPARnostic® kit (validated to measure suPAR concentrations between 0.6 and 22 ng/mL) (ViroGates)). HsCRP will be measured by high sensitivity CRP assays (Tina-quant hs-CRP latex assay (validated to measure CRP concentrations between 0.3 - 20 mg/L) (Roche/Hitachi)). In patients with CRP\>20 mg/L a regular CRP-measurement will be performed.

Timeline

• Start date: 2012-08-06
• Primary completion: 2019-06-11
• Completion: 2019-12-16
• First posted: 2020-03-03
• Last updated: 2020-03-03

Locations

1 site across 1 country: Denmark