NCT04292067

Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objective of the study aims to compare the biodiversity of intestinal microbiota between spondylarthritis (SPA) or rheumatoid arthritis (RA) patients and healthy volunteers, by microbiota DNA sequencing in order to further and respond the prior results, which suggested that there is a specific dysbiosis for each of the 2 diseases. A comparative analysis will allow to identify the biomarkers of the specific bacteria.

Detailed description

As secondary objectives, the study aims to analyse the relation between different clinical parameters such as age, gender, duration of the disease, or the nature of ongoing treatment, and the the composition of intestinal microbiota, and identify dysbiosis of bacteria, which will be specific functional signatures of intestinal microbiota in SPA and/or RA. Analyse the relation between metabolome of faecale and plasma and the composition of intestinal microbiota. This study will be performed in the rheumatology department in Ambroise Paré hospital of APHP group in France.

Conditions

• Spondyloarthritis
• Rheumatoid Arthritis

Interventions

Type	Name	Description
BIOLOGICAL	Faecal sampling	Faecal sampling at baseline
BIOLOGICAL	Blood sampling	Blood sampling at baseline

Timeline

• Start date: 2020-11-23
• Primary completion: 2026-11-01
• Completion: 2026-11-01
• First posted: 2020-03-02
• Last updated: 2025-06-15

Locations

1 site across 1 country: France