NCT04288375

Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

Reduction of Dose and Volume in Postoperative Radiation for Extremity Soft Tissue Sarcoma

• Status: Active Not Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators are doing this study to find out whether lowering the dose of postoperative radiation therapy and targeting a smaller area of tissue for treatment is as effective as the standard dose and volume of radiation therapy to control soft tissue sarcoma after surgery. They also want to find out whether the study approach causes fewer and less severe long-term side effects than the standard approach.

Conditions

• Soft Tissue Sarcoma

Interventions

Type	Name	Description
RADIATION	Intensity-modulated radiation therapy (IMRT)	The prescribed dose of radiations for all patients will be 50 Gy in 25 fractions. 6MV energy photons will be used. Multi-beam IMRT plans, utilizing dynamic multileaf collimation, will be created based on the target tissue coverage and normal tissue avoidance.

Timeline

• Start date: 2020-02-26
• Primary completion: 2027-02-01
• Completion: 2027-02-01
• First posted: 2020-02-28
• Last updated: 2026-02-20

Locations

7 sites across 1 country: United States

Regulatory

• FDA-regulated device study