NCT04284904

Role of aGVHD Biomarkers on aGVHD Risks

Role of aGVHD Biomarkers on aGVHD Risks in Patients Underwent Hematopoietic Stem Cell Transplantation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: —

Summary

To establish risk rating criteria of biological protein marker, determine the role and consistency of aGVHD biomarkers in aGVHD diagnosis and aGVHD prognosis, and evaluate the the impact on non-relapse mortality and relapse and disease free survival, the multicenter study on aGVHD biomarkers detection in the patients underwent allogeneic hematopoietic stem cell transplantation was performed.

Detailed description

1. To establish standard risk rating criteria of aGVHD biomarkers; 2. To verify the role of aGVHD biomarkers monitored in predicting aGVHD risks; 3. To determine the correlation between aGVHD biomarkers monitored and aGVHD risk; 4. To carry out a observative study in patients with aGVHD treatment about therapeutic protocols and medication efficacy; 5. To predict the correlation between the high-risk patients with aGVHD and non-relapse mortality and disease free survival;

Conditions

• GVHD,Acute
• Biomarker

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	aGVHD biomarker	To verify the effectiveness of aGVHD biomarkers monitoring in predicting aGVHD risks

Timeline

• Start date: 2018-07-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2020-02-26
• Last updated: 2020-02-26

Locations

1 site across 1 country: China