NCT04283318

Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes

The Effects of Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

In a previous study investigating the effects of intermittent fasting, our research group found evidence for higher glucose excursions and a reduced insulin response after a 36 hour fasting period as compared to an overnight fasting period in healthy subjects. The aim of this research project is to investigate the effect of short and midterm fasting (12 hours versus 36 hours) on glucose metabolism, glucose regulatory hormones, insulin secretion and resting energy expenditure in healthy and obese people as well as in patients with type 2 diabetes.

Detailed description

In this clinical study, we want to examine the effects of different fasting periods (12 hours versus 36 hours) on blood sugar levels and other metabolic parameters and hormones. For this the following investigations are carried out: * Oral glucose tolerance test with detailed laboratory evaluation * Bio-impedance measurement to determine body composition (muscle and fat mass) The examinations are carried out on 4 different cohorts (normal healthy persons, obese patients, patients with type 2 diabetes and patients with type 1 diabetes).

Conditions

• Healthy
• Obesity
• Type 2 Diabetes Mellitus
• Type 1 Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	12h fasting	12h fasting (overnight)
BEHAVIORAL	36h fasting	36h fasting ( one day and two nights fasting)

Timeline

• Start date: 2018-06-13
• Primary completion: 2020-02-26
• Completion: 2022-02-28
• First posted: 2020-02-25
• Last updated: 2022-03-02

Locations

1 site across 1 country: Austria