NCT04282538

Efficacy of rTMS and tDCS as Adjunctive Rehabilitation for Cerebrovascular Disease-related Gait Dysfunction

Efficacy of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation as Adjunctive Rehabilitation for Cerebrovascular Disease-related Gait Dysfunction

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: zsneurology · Academic / Other
• Sex: All
• Age: 35 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study was a prospective, randomized, single-blind, parallel-controlled, multicenter clinical study to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation assisted rehabilitation in the treatment of cerebrovascular disease-related gait disorders.

Detailed description

This study was a prospective, randomized, single-blind, parallel-controlled, multicenter clinical study. The main purpose was to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current stimulation assisted rehabilitation in the treatment of cerebrovascular disease-related gait disorders. The secondary objective was to assess the effects of these two types of neuromodulation on cognitive, emotional, and daily living abilities.

Conditions

• Repetitive Transcranial Magnetic Stimulation
• Transcranial Direct Current Stimulation
• Cerebrovascular Disease
• Gait Dysfunction, Neurologic

Interventions

Type	Name	Description
DEVICE	Active rTMS	4-week (5 days per week) active rTMS (90%rMT, M1, 10Hz for 10s, 50s interval, 20 trains)
DEVICE	Sham rTMS	4-week (5 days per week) sham rTMS
DEVICE	Active tDCS	4-week (5 days per week) active tDCS (2mA, DLPFC, 20 min)
DEVICE	Sham tDCS	4-week (5 days per week) sham tDCS
OTHER	Walking training	4-week (5 days per week) walking training
OTHER	Cognition training	4-week (5 days per week) cognition training

Timeline

• Start date: 2018-12-01
• Primary completion: 2020-11-30
• Completion: 2020-12-31
• First posted: 2020-02-24
• Last updated: 2020-02-24

Locations

6 sites across 1 country: China