Trials / Unknown
UnknownNCT04281797
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
Intestinal Microbiome Composition Dynamics Over the Course of Kidney Transplantation, Liver Transplantation, Allogeneic Hematopoietic Stem Cells and Mesenchymal Stem Cells Transplantation
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 90 (estimated)
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology · Other Government
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells transplantation in association with the clinical outcomes.
Detailed description
This is a pilot study designed to investigate the dynamic changes in the intestinal microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic HSCs and mesenchymal stem cells transplantation. Four patient cohorts will be followed. Cohort A: patients receiving kidney transplantation. Cohort B: patients receiving hematopoietic stem cells transplantation. Cohort C: patients receiving mesenchymal stem cells transplantation. Cohort D: patients receiving liver transplantation. Included participants are defined as patients with at least three analyzable stool samples including a baseline sample before the transplantation.
Conditions
- Transplantation Infection
- Kidney Transplant; Complications
- Stem Cell Transplant Complications
- Liver Transplant; Complications
- Microbial Colonization
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Intestinal microbiome new generation sequencing | Fecal samples collected at baseline pre-transplant and post-transplant, new generation 16s RNA sequencing performed. |
Timeline
- Start date
- 2020-01-01
- Primary completion
- 2022-12-31
- Completion
- 2023-06-30
- First posted
- 2020-02-24
- Last updated
- 2022-08-31
Locations
1 site across 1 country: Belarus
Source: ClinicalTrials.gov record NCT04281797. Inclusion in this directory is not an endorsement.