Trials / Recruiting
RecruitingNCT04280510
Pathogenic Study of Adult Immune Enteropathies
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | Blood sample collection; gastrointestinal biopsy | Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage... |
Timeline
- Start date
- 2020-02-27
- Primary completion
- 2030-02-27
- Completion
- 2033-02-27
- First posted
- 2020-02-21
- Last updated
- 2025-09-18
Locations
4 sites across 1 country: France
Source: ClinicalTrials.gov record NCT04280510. Inclusion in this directory is not an endorsement.