Trials / Completed
CompletedNCT04276220
Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery
Prevalence of Wild-Type Transthyretin Cardiac Amyloidosis Among Patients Undergoing Carpal Tunnel Release Surgery - A Prospective Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 109 (actual)
- Sponsor
- Steen Hvitfeldt Poulsen · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
Patients above the age of 60 will be recruited at their carpal tunnel release surgery. Biopsies will be taken from the wrist and examined for the presence of amyloid protein. A amyloid-positive biopsy will refer the patients for cardiac examination including blod- and urine samples examined for transthyretin. If the result of the cardiac examination is suspected cardiac amyloidosis, the patient will be referred for a diagnostic TC99-DPD scintigraphy. If the scintigraphy is positive, the patient will be referred for right heart catherization (RHC) and an exercise test. Myocardial biopsies will be taken at the RHC and examined with electron microscopy and high resolution respirometry.
Conditions
- Transthyretin Amyloidosis
- Transthyretin Cardiac Amyloidosis
- Wild-Type Transthyretin-Related (ATTR)Amyloidosis
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Tenosynovial biopsy | Tenosynovial biopsy taken from the wrist at the carpal tunnel release surgery. |
Timeline
- Start date
- 2020-04-01
- Primary completion
- 2025-05-21
- Completion
- 2025-05-21
- First posted
- 2020-02-19
- Last updated
- 2025-08-15
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04276220. Inclusion in this directory is not an endorsement.