NCT04275037

The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: University Institute of Maia · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

New data suggests that isometric handgrip training (IHT) might become a novel tool in the treatment of hypertension. The main purpose of this research project is to evaluate the effects of home-based IHT on ambulatory blood pressure in older adults with pre-hypertension and hypertension. Eighty-four older adults with pre-hypertension and hypertension will be randomly distributed to one of three groups: home-based IHT, home-based aerobic exercise training (AET), or attention-control group (CON). Each intervention will have a total duration of 8 weeks. At baseline and after completing the intervention, patients will undergo the following evaluations: 24-hour ambulatory blood pressure, cardiorespiratory fitness, endothelial function, damage and repair, arterial stiffness, inflammatory biomarkers, autonomic function, physical activity levels, dietary intake and quality of life. A qualitative analysis will also be applied to enhance the understanding of the efficacy of this intervention from the patient's perspective.

Conditions

• Hypertension
• Pre-Hypertension

Interventions

Type	Name	Description
OTHER	Isometric Handgrip Training	The 8-week exercise program will include three sessions of isometric handgrip training per week
OTHER	Aerobic Exercise Training	The 8-week exercise program will include three sessions of aerobic exercise per week

Timeline

• Start date: 2021-04-12
• Primary completion: 2023-01-30
• Completion: 2023-01-30
• First posted: 2020-02-19
• Last updated: 2023-05-22

Locations

10 sites across 2 countries: United States, Portugal