NCT04274790

Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer

Analysis of the Impact of 5-Fluorouracil on the Translational Control and Plasticity of Cancer Cells From Liver Metastases of Colon Cancer

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Centre Leon Berard · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Analyze the dynamics of incorporation of 5-fluorouracil into cancer cell ribosomes from liver metastases of patient with metastatic colon cancer.

Detailed description

This is a monocentric, prospective, non-interventional cohort study in adult patients with metastatic colon cancer with hepatics metastasis. Tumour samples collected for this study include: * A fragment of the previously operated primary tumor: FFIP block and/or archived frozen tumor if available. * A fragment of the liver metastasis(s) performed as part of standard metastasis surgery, this fragment will include a tumor area and a healthy area within the margin of excision. These samples collected in a fresh state will be analyzed immediately.

Conditions

• Cancer of Colon
• Metastasis to Liver

Interventions

Type	Name	Description
PROCEDURE	Scheduled and planned surgery	Collection of tumour samples from samples collected as part of standard patient management. Diagnostic pathological analysis will be a priority. These samples will be taken by experienced staff during the hospital visit scheduled as part of standard care.

Timeline

• Start date: 2021-06-01
• Primary completion: 2023-03-01
• Completion: 2023-03-01
• First posted: 2020-02-18
• Last updated: 2024-02-14

Locations

1 site across 1 country: France