NCT04274348

Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum

Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical studies have demonstrated a link between staphylococcal skin colonization and the pathogenesis of AD, but the implication of bacterial virulence factors remains largely uncharacterized. Finally, AD is often associated with herpes simplex skin infections. The aim of this project is to investigate the role of staphylococcal toxins in the exacerbation and maintenance of atopic skin inflammation and in the occurrence of infectious complications such as eczema herpeticum.

Conditions

• Atopic Dermatitis
• Staphylococcus Aureus
• Bacterial Toxins
• Immune Response
• Cytokines
• T Cells Subsets

Interventions

Type	Name	Description
OTHER	Skin biopsies and blood samples	Two skin biopsies and 30 ml of blood will be collected.

Timeline

• Start date: 2020-10-15
• Primary completion: 2025-08-04
• Completion: 2025-08-04
• First posted: 2020-02-18
• Last updated: 2025-12-29

Locations

2 sites across 1 country: France