NCT04273399

High-impact Exercise in Adults With Crohn's Disease

Feasibility of High-impact Exercise to Improve Musculoskeletal Outcomes in Adults With Crohn's Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: NHS Greater Glasgow and Clyde · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Crohn's disease increases the risk of poor musculoskeletal health, as the inflammatory disease process directly inhibits regulatory pathways involved in bone and muscle formation and maintenance. The negative effects of disease on muscle-bone health are compounded by poor nutritional status, vitamin d deficiency, prolonged exposure to glucocorticoid therapy, and reduced physical activity. Modern, steroid sparing therapies are successful at inducing clinical remission in terms of inflammation, however they have limited effect in remedying observed muscle-bone deficits. Subsequently, patients with Crohn's disease are at increased lifelong risk of pathological fractures and osteoporosis. Novel adjunctive therapies are therefore required to complement pharmacological treatments and target muscle-bone deficits, which are responsible for significant disease burden in Crohn's. High-impact exercise may be a useful additional therapy for patients with Crohn's disease, as the mechanical strains produced during this type of exercise, through large magnitude muscular contractions and ground reaction forces, can promote bone formation and gains in muscle mass. There have been no previous studies assessing the effects of high impact exercise in Crohn's disease, so it is unknown if this type of exercise is safe and feasible in this population. The aim of this study is to assess the feasibility of high-impact exercise for improving markers of bone and muscle health in adults with Crohn's disease, and compare the effects of exercise with a group of healthy age and sex matched controls.

Conditions

• Crohn Disease

Interventions

Type	Name	Description
OTHER	High-impact exercise intervention	* Twelve-week high-impact exercise intervention * Majority home based sessions, some supervised sessions * Three exercise sessions per week * Between 50 - 100 jumps per session * Progressive jumping exercises to increase mechanical loading
OTHER	Acute response to high-impact exercise	* First session of twelve-week high-impact exercise session used to assess the acute physiological response to one session of high-impact exercise in both Crohn's disease and healthy controls * One supervised session of high-impact exercise * Bloods to assess acute inflammatory and bone turnover response post-exercise

Timeline

• Start date: 2020-03-01
• Primary completion: 2021-10-01
• Completion: 2021-10-01
• First posted: 2020-02-18
• Last updated: 2020-02-18

Locations

1 site across 1 country: United Kingdom