NCT04273334

Application of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic Disorders

Application of 68Ga NEB PET Imaging in the Diagnosis and Evaluation of Lymphatic Disorders, Including Lymphedema, Lymphangioma, Lymphangioleiomyomatosis, Plastic Bronchitis, Lymphadenopathy Caused by Rheumatoid Arthritis, Etc.

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is an open-label whole-body PET/CT study for investigating the value of 68Ga NEB PET imaging in the diagnosis and evaluation of lymphatic disorders including lymphedema, lymphangioma, lymphangioleiomyomatosis, plastic bronchitis, lymphadenopathy caused by rheumatoid arthritis, etc.

Detailed description

No fasting, hydration or other specific preparation was requested on the day of imaging. Patients for lymphatic drainage disorders imaging underwent whole-body PET/CT acquisitions 20-40 min after subcutaneously injected into first and second interdigital spaces of both feet or hands of 74-111 MBq (2-3 mCi) 68Ga-NEB with each bed position lasted for 2 min. A MIM workstation was used for post-processing. The visual method was used to evaluate the lymphatic system, including the morphology and the distribution of the lymphatic system. Semiquantitative methods were applied for image analysis.

Conditions

• Lymphatic Disorders

Interventions

Type	Name	Description
DRUG	68Ga-NEB	68Ga-NEB were injected into the patients before the PET/CT scans

Timeline

• Start date: 2019-10-01
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2020-02-18
• Last updated: 2020-02-18

Locations

1 site across 1 country: China